Hotkeying Control Groups

Hey guy's, I'm having the most difficult time trying to find out comfortable hotkeys!

I can't decide if I want to do 1-3 units and 4+ builings, or vice versa.  My problem comes from that 1-4 are the most comfortable buttons to press.  Anything 5+ feelings uncomfortable because I feel like I need to shift my hand too much.

I've tried hotkeying control groups on the side buttons of my mouse but that ends up putting too much business for my right hand.

Maybe I'm just not practicing one set of hotkeys enough.  Any suggestions?